To see a world in a grain of sand
And a heaven in a wild flower William Blake Yang’s Group

Publications

After Joined OU:

Column Article

1. W. Rao, N. Pan, Z. Yang*, “Single-Cell MS and High-Spatial-Resolution MS Imaging Under Ambient Conditions Using a Novel Sampling Device”, LCGC North America 2015, 33, 414–419.

Book Chapter

1. N. Pan, W. Rao, Z. Yang*, Single-Probe Mass Spectrometry Analysis of Metabolites in Single Cells. In: Shrestha B. (eds) Single Cell Metabolism. Methods in Molecular Biology, 2020, vol. 2064. Humana, New York, NY.


Editorial Article (peer reviewed)

1. A. Svatoš*, Y. J. Lee, and Z. Yang, “Single Plant Cell Metabolomics”, Front. Plant Sci., 2020, 11, 161.


Patent

(1) Z. Yang, Cellular Probe Device, System and Analysis Method, ID Number: U.S. Serial No. 9,595,428 and 10,000,789.


Peer-reviewed Publications

78. R. Bensen, S. Standke, D. Colby, N. Kothapalli, A. Le, M. A. Patten, A. Tripathi, J. Heinlen, Z. Yang*, A. Burgett*, “Single Cell Mass Spectrometry Quantification of Anticancer Drugs: Proof of Concept in Cancer Patients”, ACS Pharmacol. Transl. Sci., in press.

77. R. Liu, Z. Yang*, “Single Cell Metabolomics Using Mass Spectrometry: Techniques and Data Analysis”, Anal. Chim. Acta, 2021, 1143, 124-134.

76. Z. Pei, J. Yang, J. Deng, Y. Mao, Q. Wu, Z. Yang, B. Wang, C. M. Aikens, W. Liang*, and Y. Shao*, “Visualization and Analysis of Energy Densities: II. Linear-Response Time-Dependent Density Functional Theory Calculations”, Phys. Chem. Chem. Phys., 2020, 22, 26852-26864.

75. J. Yang, Z. Pei, J. Deng, Y. Mao, Q. Wu, Z. Yang, B. Wang, C. M. Aikens, W. Liang*, and Y. Shao*, “Visualization and Analysis of Energy Densities: I. Real-Time Time-Dependent Density Functional Theory Simulations”, Phys. Chem. Chem. Phys., 2020, 22, 26838-26851.

74. Y. Zhu, W. Wang, Z. Yang*, “Combining Mass Spectrometry with Paternò-Büchi Reaction to Determine Double-bond Positions in Lipids at the Single-cell Level”, Anal. Chem. 2020, 92, 11380-11387.

73. M. Liu, Y. Zhang, J. Yang, X. Cui, Z. Zhou, H. Zhan, K. Ding, X. Tian, Z. Yang, K. A. Fung, B. H. Edil, R. G. Postier, M. S. Bronze, M. E. Fernandez-Zapico, M. P. Stemmler, T. Brabletz, Y. Li, C. W. Houchen, M. Li*, “ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells”, Gastroenterology, 2020, 158, 679–692.

72. Y. Tao, N. Bellonzi, Y. Mao, Z. Pei, Z. Zou, Z. Yang, Y. Shao*, “Constructing Spin-Adiabatic States for the Modeling of Spin-Crossing Reactions. I. A Shared-Orbital Implementation”, Int. J. Quantum Chem. 2020, 120, e26123.

71. R. Liu, M. Sun, G. Zhang, Y. Lan, Z. Yang*, “Towards Early Monitoring of Chemotherapy-Induced Drug Resistance Based on Single Cell Metabolomics: Combining Single-probe Mass Spectrometry with Machine Learning”, Anal. Chim. Acta, 2019, 1092, 42-48.

70. X. Tian, B. Xie, Z. Zou, Y. Jiao, L. Lin, C. Chen, C. Hsu, J. Peng*, Z. Yang*, “Multimodal Imaging of Amyloid Plaques: Fusion of the Single-probe Mass Spectrometry Image and Fluorescence Microscopy Image”, Anal. Chem. 2019, 91, 12882-12889.

69. Y. Zhu, R. Liu, Z. Yang*, “Redesigning the T-probe for Mass Spectrometry Analysis of Online Lysis of Non-adherent Single Cells”, Anal. Chim. Acta, 2019, 1084, 53-59.

68. N. Pan, S. Standke, N. R. Kothapalli, M. Sun, R. C. Bensen, A. Burgett, Z. Yang*, “Quantification of Drug Molecules in Live Single Cells using the Single-probe Mass Spectrometry Technique”, Anal. Chem. 2019, 91, 9018-9024.

67. S. Standke, D. Colby, R. Bensen, A. Burgett*, Z. Yang*, “Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells”, J. Vis. Exp., 2019, 148, e5987.

66. X. Tian, G. Zhang, Z. Zou, Z. Yang*, “Anticancer Drug Affects Metabolomic Profiles in Multicellular Spheroids: Studies Using Mass Spectrometry Imaging Combined with Machine Learning”, Anal. Chem. 2019, 91, 5802-5809.

65. R. Liu, G. Zhang, M. Sun, X. Pan, Z. Yang*, “Integrating A Generalized Data Analysis Workflow with the Single-probe Mass Spectrometry Experiment for Single Cell Metabolomics”, Anal. Chim. Acta 2019, 1064, 71-79.

64. B. L. Roberts, Z. C. Severance, R. C. Bensen, A. T. Le, N. R. Kothapalli, J. I. Nuñez, H. Ma, S. Wu, S. J. Standke, Z. Yang, W. J. Reddig, E. L. Blewett, A. W. G. Burgett*, “Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity”, ACS Chem. Biol. 2019, 14, 276-287 (ACS Editors' Choice).

63. M. Sun, Z. Yang*, “Metabolomic Studies of Live Single Cancer Stem Cells Using Mass Spectrometry”, Anal. Chem. 2019, 91, 2384-2391.

62. S. Standke, D. Colby, R. Bensen, A. Burgett*, Z. Yang*, “Mass Spectrometry Measurement of Single Suspended Cells using Combined Cell Manipulation System and the Single-probe Device”, Anal. Chem. 2019, 91, 1738-1742.

61. R. Liu, G. Zhang, Z. Yang*, “Towards Rapid Prediction of Drug-resistant Cancer Cell Phenotypes: Single Cell Mass Spectrometry Combined with Machine Learning”, Chem. Comm. 2019, 55, 616-619.

60. R. Liu, N. Pan, Y. Zhu, Z. Yang*, “T-Probe: An Integrated Microscale Device for Online In Situ Single Cell Analysis and Metabolic Profiling Using Mass Spectrometry”, Anal. Chem. 2018, 90, 11078−11085.

59. M. Sun, Z. Yang, B. Wawrik*, “Metabolomic Fingerprints of Individual Algal Cells Using the Single-Probe Mass Spectrometry Technique”, Front. Plant Sci. 2018, 9:571.

58. X. Tian, G. Zhang, Y. Shao*, Z. Yang*, “Towards Enhanced Metabolomic Data Analysis of Mass Spectrometry Image: Multivariate Curve Resolution and Machine Learning”, Anal. Chim. Acta 2018, 1037, 211-219.

57. L. Du, A. L. Risinger, C. A. Mitchell, J. You, B. W. Stamps, N. Pan, J. B. King, J. C. Bopassa, S. I. V. Judge, Z. Yang, B. S. Stevenson, and R. H. Cichewicz*, “A Unique Amalgamation of Primary and Secondary Structure Attributes Transform Peptaibols into Potent Bioactive Cell-Penetrating Peptides”, Proc. Natl. Acad. Sci. 2017, 114, E8957-E8966.

56. B. Wawrik*, D. A. Bronk, S. E. Baer, L. Chi, M. Sun, J. T. Cooper, Z. Yang, “Bacterial Utilization of Creatine in Seawater”, Aquat. Microb. Ecol. 2017, 80, 153−165.

55. M. Sun, X. Tian, Z. Yang*, “Microscale Mass Spectrometry Analysis of Extracellular Metabolites in Live Tumor Spheroids”, Anal. Chem. 2017, 89, 9069−9076.

54. N Pan, W. Rao, Shawna J. Standke, Z. Yang*, “Using Dicationic Ion-Pairing Compounds to Enhance the Single Cell Mass Spectrometry Analysis using the Single-probe: A Microscale Sampling and Ionization Device”, Anal. Chem. 2016, 88, 6812−6819.

53. W. Rao, N. Pan, Z. Yang*, “Applications of the Single-Probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions”, J. Vis. Exp. 2016, 112, e53911, doi:10.3791/53911.

52. C. M. Nichols, Z.-C., Wang, Z. Yang, W. C. Lineberger, V. M. Bierbaum*, “Experimental and Theoretical Studies of the Reactivity and Thermochemistry of Dicyanamide: N(CN)2”, J. Phys. Chem. A 2016, 120, 992–999.

51. W. Rao, N. Pan, X. Tian, Z. Yang*, “High-Resolution Ambient MS Imaging of Negative Ions in Positive Ion Mode: Using Dicationic Reagents with the Single-probe”, J. Am. Soc. Mass Spectrom. 2016, 27, 124–134.

50. W. Rao, N. Pan, Z. Yang*, “High Resolution Tissue Imaging using the Single-probe Mass Spectrometry under Ambient Conditions”, J. Am. Soc. Mass Spectrom. 2015, 26, 986-993.

49. Z. Yang*, N. Pan, “Computational Studies of Ion-neutral Reactions of Astrochemical Relevance: Formation of Hydrogen Peroxide, Acetamide, and Amino Acetonitrile”, Int. J. Mass Spectrom. 2015, 353, 1– 6.

48. N. Pan, W. Rao, N. Kothapalli, R. Liu, A. Burgett*, Z. Yang*, “The Single-probe: a Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis”, Anal. Chem. 2014, 86, 9376–9380.

47. N. J. Demarais; Z. Yang, T. P. Snow, V. M. Bierbaum*, “Gas-Phase Reactions of Polycyclic Aromatic Hydrocarbon Cations and their Nitrogen-containing Analogues with H atoms”, Astrophys. J. Astrophys. J. 2014, 784:25 (7pp).

46. C. A. Cole, N. J. Demarais, Z. Yang, T. P. Snow, V. M. Bierbaum*, “Heterocyclic Anions of Astrobiological Interest”, Astrophys. J. 2013, 779:181 (9pp).

45. C. M. Nichols, Z. Yang, V. M. Bierbaum*, “Gas-phase organic reactions of the atomic oxygen radical cation”, Int. J. Mass Spectrom. 2013, 353, 1–6.

44. N. J. Demarais, Z. Yang, T. P. Snow, V. M. Bierbaum*, "Chemistry of HCNH+: Mechanisms, Structures, and Relevance to Titan’s Atmosphere”, Struct. Chem. 2013, 24, 1957–1963.

43. Z. Lin, D. Talbi, E. Roueff, E. Herbst,* N. Wehres, C. A. Cole, Z. Yang, T. P. Snow, V. M. Bierbaum, “Can Interstellar Propene (CH3CHCH2) Be Formed via Gas-Phase Reactions?”, Astrophys. J. 2013, 765:80 (5pp).

42. C. M. Nichols, Z. Yang, B. B. Worker, D. R. Hager, N. M. M. Nibbering, V. M. Bierbaum*, “Gas-phase Reactions of the Atomic Oxygen Radical Cation with Halogenated Compounds”, Phys. Chem. Chem. Phys. 2013, 15, 561-567.


Before Joined OU:

41. J. M. Garvera, Z. Yang, N. Wehres, C. M. Nichols, B. B. Workera, V. M. Bierbaum*, “The α-effect in Elimination Reactions and Competing Mechanisms in the Gas Phase”, Int. J. Mass Spectrom. 2012, 330-332, 182-190.

40. C. A. Cole, N. Wehres, Z. Yang, D. L. Thomsen, T. P. Snow, V. M. Bierbaum*, “A Gas-phase Formation Route to Interstellar Trans-methyl Formate”, Astrophys. J. 2012, 754:L5 (4pp).

39. J. M. Garver, Z. Yang, C. Nichols, B. Worker, S. Gronert, V. M. Bierbaum*, “Resolving the α-effect in Gas Phase SN2 Reactions: A Marcus Theory Approach”, Int. J. Mass Spectrom. 2012, 316-318, 244-250.

38. J. Laskin*, Z. Yang, C. Lam, I. K. Chu, “Entropy Effects on the Proton and Radical Mobility in Gas-Phase Peptide Ions”, Int. J. Mass Spectrom. 2012, 316-318, 252-258.

37. Z. Yang, M. T. Rodgers*, “Tautomerization in the Formation and Collision-Induced Dissociation of Alkali Metal Cation-Cytosine Complexes”, Phys. Chem. Chem. Phys. 2012, 14, 4517-4526.

36. N. J. Demarais, Z. Yang, O. Martinez Jr., N. Wehres, T. P. Snow, V. M. Bierbaum*, “Gas-Phase Reactions of Polycyclic Aromatic Hydrocarbon Anions with Molecules of Interstellar Relevance”, Astrophys. J. 2012, 746:32 (6pp).

35. Z. Yang, C. A. Cole, O. Martinez Jr., M. Y. Carpenter, T. P. Snow, V. M. Bierbaum*, “Experimental and Theoretical Studies of Reactions between H Atoms and Nitrogen-containing Carbanions”, Astrophys. J. 2011, 739:19 (10pp).

34. J. Laskin*, Z. Yang, “Energetics and Dynamics of Dissociation of Deprotonated Peptides: Fragmentation of Angiotensin Analogs”, Int. J. Mass Spectrom. 2011, 308, 275-280.

33. J. M. Garver, Z. Yang, S. Kato, S. W. Wren, K. M. Vogelhuber, W. C. Lineberger, V. M. Bierbaum*, “Gas Phase Reactions of 1,3,5-Triazine: Proton Transfer, Hydride Transfer and Anionic σ-Adduct Formation”, J. Am. Soc. Mass Spectrom. 2011, 22, 1260-1272.

32. J. Laskin*, Z. Yang, A. S. Woods, “Competition between Covalent and Noncovalent Bond Cleavages in Dissociation of Phosphopeptide-Amine Complexes”, Phys. Chem. Chem. Phys. 2011, 13, 6936-6946.

31. J. M. Garver, N. Eyet, S. M. Villano, Z. Yang, V. M. Bierbaum*, “Mechanistic Investigation of SN2 Dominated Gas Phase Alkyl Iodide Reactions”, Int. J. Mass Spectrom. 2011, 301, 151-158.

30. J. Laskin*, Z. Yang, T. Song, C. Lam, I. K. Chu, “The Effect of the Basic Residue on the Energetics, Dynamics, and Mechanisms of Gas-Phase Fragmentation of Protonated Peptides”, J. Am. Chem. Soc. 2010, 132, 16006-16016.

29. Z. Yang, B. Eichelberger, M. Y. Carpenter, O. Martinez Jr., T. P. Snow, V. M. Bierbaum*, “Experimental and Theoretical Studies of Reactions between H Atoms and Carbanions of Interstellar Relevance”, Astrophys. J. 2010, 723, 1325-1330.

28. Z. Yang*, T. P. Snow, V. M. Bierbaum*, “Computational Studies of Gas Phase Reactions of Carbon Chain Anions with N and O Atoms”, Phys. Chem. Chem. Phys. 2010, 12, 13091-13098.

27. O. Martinez Jr., Z. Yang, N. J. Demarais, T. P. Snow, V. M. Bierbaum*, “Gas-Phase Reactions of Hydride Anion, H”, Astrophys. J. 2010, 720, 173-177.

26. Z. Yang*, B. Eichelberger, O. Martinez Jr., M. Stepanovic, T. P. Snow*, V. M. Bierbaum*, “The Influence of Spin Effects on the Gas Phase Reactions of Carbanions with N and O Atoms”, J. Am. Chem. Soc. 2010, 132, 5812-5819.

25. J. Laskin*, Z. Yang, C. M. Dominic Ng, I. K. Chu, “Fragmentation of α-Radical Cations of Arginine-Containing Peptides”, J. Am. Soc. Mass Spectrom. 2010, 21, 511-521.

24. O. Martinez Jr., Z. Yang, N. B. Betts, T. P. Snow, V. M. Bierbaum*, “Experimental Determination of the Rate Constant for the Associative Detachment Reaction H + H → H2 + e at 300 K”, Astrophys. J. 2009, 705, L172-L175.

23. Z. Yang, E. R. Vorpagel, J. Laskin*, “Influence of the Charge State on the Structures and Interactions of Vancomycin Antibiotics with Cell-Wall Analogue Peptides: Experimental and Theoretical Studies”, Chem. Eur. J. 2009, 15, 2081-2090.

22. Z. Yang, E. R. Vorpagel, J. Laskin*, “Experimental and Theoretical Study of the Structures and Interactions of Vancomycin Antibiotics with Cell Wall Analogues”, J. Am. Chem. Soc. 2008, 130, 13013-13022.

21. Z. Yang, C. Lam, I. K. Chu, J. Laskin*, “The Effect of the Secondary Structure on Dissociation of Peptide Radical Cations: Fragmentation of Angiotensin III and Its Analogues”, J. Phys. Chem. B 2008, 112, 12468-12478.

20. J. Laskin*, Z. Yang, I. K. Chu, “Energetics and Dynamics of Electron Transfer and Proton Transfer in Dissociation of MetalIII(salen)-Peptide Complexes in the Gas-Phase”, J. Am. Chem. Soc. 2008, 130, 3218-3230.

19. Z. Yang, N. S. Rannulu, Y. Chu, M. T. Rodgers*, “Bond Dissociation Energies and Equilibrium Structures of Cu+(MeOH)x, x =1 − 6, in the Gas Phase: Competition Between Solvation of the Metal Ion and Hydrogen Bonding Interactions”, J. Phys. Chem. A 2008, 112, 388-401.

18. C. Ruan, Z. Yang, M. T. Rodgers*, “Influence of the d Orbital Occupation on the Nature and Strength of Binding Copper Cation-π Interactions: Threshold Collision-Induced Dissociation and Theoretical Studies”, Phys. Chem. Chem. Phys. 2007, 9, 5902-5918.

17. C. Ruan, Z. Yang, M. T. Rodgers*, “Cation-π interactions with a π-Excessive Nitrogen Heterocycle: Structures and Absolute Binding Energies of Alkali Metal Cation–Pyrrole Complexes”, Int. J. Mass Spectrom. 2007, 267, 233-247.

16. J. Laskin*, Z. Yang, C. Lam, I. K. Chu, “Charge-Remote Fragmentation of Odd-Electron Peptide Ions”, Anal. Chem. 2007, 79, 6607-6614.

15. Z. Yang, C. Ruan, H. Ahmed, M. T. Rodgers*, “Probing the Potential Energy Landscape for Dissociation of Protonated Indole via Threshold Collision-Induced Dissociation and Theoretical Studies”, Int. J. Mass Spectrom. 2007, 265, 388-400.

14. Z. Yang, O. Hadjar, J. Laskin*, “Effect of the surface morphology on the energy transfer in ion–surface collisions”, Int. J. Mass Spectrom. 2007, 265, 124-129.

13. Z. Yang, M. T. Rodgers*, “The Influence of Thio-Substitution on Noncovalent Interactions of Uracil with Alkali Metal Ions. Threshold Collision-Induced Dissociation and Theoretical Studies”, J. Phys. Chem. A 2006, 110, 1455-1468.

12. Z. Yang, M. T. Rodgers*, “Influence of Methylation on the Properties of Uracil and Its Noncovalent Interactions with Alkali Metal Ions. Threshold Collision-Induced Dissociation and Theoretical Studies”, Int. J. Mass Spectrom. 2005, 241, 225-242.

11. C. Ruan, Z. Yang, N. Hallowita, M. T. Rodgers*, “Cation-Pi Interactions with a Model for the Side Chain of Tryptophan: Structures and Absolute Binding Energies of Alkali Metal Cation-Indole Complexes”, J. Phys. Chem. A 2005, 109, 11539-11550.

10. Z. Yang, M. T. Rodgers*, “Influence of Halogenation on the Properties of Uracil and Its Noncovalent Interactions with Alkali Metal Ions. Threshold Collision-Induced Dissociation and Theoretical Studies”, J. Am Chem. Soc. 2004, 126, 16217-16226.

9. Z. Yang, M. T. Rodgers*, “Theoretical Study of the Unimolecular and Bimolecular Tautomerization of Cytosine”, Phys. Chem. Chem. Phys. 2004, 6, 2749-2757.

8. N. Rannula, R. Amunugamma, Z. Yang, M. T. Rodgers*, “Influence of s and d Orbital Occupation on the Binding of Metal Ions to Imidazole”, J. Phys. Chem. A. 2004, 108, 6385-6396.

7. Y. Chu, Z. Yang, M. T. Rodgers*, “Solvation of Cu+ by Acetone. Structures and Sequential Binding Energies of Cu+(acetone)x, x = 1 − 4 from Collision-Induced Dissociation and Theoretical Studies”, J. Am. Soc. Mass Spectrom. 2002, 13, 453-468.

6. L. Xiao, P. Lin*, W. Wang, Z. Yang, Y. Fu, S. Yu, “A Novel Preparation Route of Three-way Catalysts”, Top. Catal. 2001, 16/17, 107-113.

5. Z. Yang, P. Lin*, W. Wang, S. Yu, “Study of CeO2−ZrO2 Solid Solution Promoter Modified by Nd”, Chinese J. Catal. (In Chinese) 2001, 22, 365-369.

4. Z. Yang, P. Lin*, L. Xiao, S. Yu, “CeO2−ZrO2 Solid Solutions Prepared by Modified Sol-Gel Method and Their Characteristics”, J. Funct. Mater. (In Chinese) 2000, 31, 657-659.

3. L. Xiao, P. Lin*, Z. Yang, W. Wang, “The Phase Purity and Effects on Three-way Catalysts of CeO2-ZrO2 Solid Solutions”, J. Mol. Catal. (In Chinese) 2000, 14, 81-86.

2. L. Xiao, P. Lin*, Z. Yang, G. Bian, “The Effect of ZrO2 on the Rh/g−Al2O3 Catalyst for NO Catalytic Reduction”, Chinese J. Chem. Phys. (In Chinese) 2000, 13, 329-335.

1. X. Zhang*, Z. Xie, Z. Yang, “A Discussion on Discriminating the Production Sites of the Ancient Pottery by Using Isotopic Ratios”, Acta Goescientia Sinica (In Chinese) 1997, 18, 307-309.